The literature search and the material extracted from that search, while not necessarily representing all publications in the field, yielded 1244 stand alone articles on ‘successful aging’, 49 PUBMED research reports on ‘successful aging and COVID-19’, plus 15 on ‘lockdowns’ and aging, 43 on the ‘immune system and social isolation’. The posted research and reviews were highly diverse, however, and attempts were hence made as a result to narrow the current search and discussion primarily to the social and emotional impacts of lockdowns on overall life quality among older freely living adults desiring to age in place.

This idea was based on a study of the experiences of older people by Heid et al. 7 who found the experiences appraised as most difficult by participants fell into 8 domains: Social Relationships, Activity Restrictions, Psychological, Health, Financial, Global Environment, Death, and Home Care. The most frequently appraised challenges moreover, were constraints on social interactions (42.4%) and restrictions on activity (30.9%). However as pointed out by Burlacu et al. 4 epidemiological arguments favoring self-isolation during the COVID-19 pandemic are widely recommended, while the consequences of social isolation/loneliness of older people considered to be at higher risk for severe illness are neglected, even while they are disproportionately affected. In addition, as outlined by Lim et al. 8 it is important to not only evaluate the impacts of COVID-19 on older people, but to potentially balance the successful pandemic control of COVID-19 with active with proactive management approaches to avert current as well as future negative albeit modifiable secondary and negative health outcomes and their possible undesirable consequences.

In this regard, Yeung et al. 5 imply that comprehensive efforts to promote successful aging perceptions, despite lockdown restrictions, are more likely than not to be helpful in fostering adequate levels of physical and psychosocial functioning, as well as higher resilience levels, affective signs of wellbeing and fewer depressive symptoms, along with heightened rates of premature mortality. Moreover, research indicated that older adults who exhibit adaptive rather than maladaptive regulatory behaviors are more likely to be able to regulate their emotions and proactively deal with future stressors, the occurrence or persistence of negative events or potential losses in response to the pandemic.

However, achieving this state may be especially challenging if key mental and physical health determinants are compromised in the context of social distancing imperatives that prevail for COVID-19 to a high degree 69.

As outlined in the current literature, the widespread lockdowns that persist in 2021 and that have imposed extended periods of social isolation quite unexpectedly as an outcome of multiple socially restrictive pandemic rulings to avert infection and fatalities, may prove especially challenging for many older adults in the community who either live alone or are less able than others to live independently, while being denied resource access, and others, especially in the medical sphere 1011. As well, excess loneliness and fears that have been engendered 12, may not only impact mental wellbeing quite markedly, regardless of overall health status and age, but physical wellbeing, as well as cognitions, which are all important analogues of ‘successful aging’. Those who have limited economic and technical resources, along with those who have become increasingly frail or debilitated are in turn, more likely than not to succumb to COVID-19 infections, especially if they feel a threat to their mental and physical health directly tied to their quarantine and restricted state as outlined by Daly et al. 13. Their emotionally charged and declining activity based participation, could also be expected to impact unfavorably on many body systems, thus raising the risk of incurring one or more chronic diseases, or increasing their concurrent severity, and thereby, all cause mortality rates that could rival clinical factors, such as obesity 11.

As discussed by Acquisto and Hamilton 14, this persistent imposition of physical and social restrictions, and a pervasive inability of the older home bound adult to interact socially with important others, both formal, as well as informal, is likely to affect the body quite negatively and substantively in a threefold manner, that is at the physiological, psychological, and behavioral levels. Unsurprisingly, social isolation in its own right, may be an independent risk factor for obesity and others harmful physiological states, as well as excess weight loss and frailty. In addition, excess feelings of depression, and lack of direct care access, may heighten the need for pain killing drugs and harmful addictive substances 12. Loneliness, a potential consequence of being forced to socially distance without respite, is also an independent risk factor for cardiovascular disease, a key risk factor for COVID-19 disease. 

It is no surprise therefore that Labreusseur et al. 15 who recently examined 135 publication records related to COVID-19 found the presence of psychological symptoms, the exacerbation of ageism, and the physical deterioration of aged populations to be quite common. As well, decreases in social life events and interactions reported during the pandemic were occasionally associated with a reduced life quality and increased feeling of depression. Difficulties accessing services, sleep disturbances and a reduction of physical activity were also noted.

As related to the COVID-19 pandemic, Kotwal et al. 16 found those elderly participants they interviewed to have experienced social isolation in 40% of cases, while 76% reported minimal video-based socializing, and 42% reported minimal Internet-based socializing. In addition, socially isolated participants reported difficulty finding help with functional needs including bathing (20% vs 55%; P = .04), and more than half (54%) of the participants reported worsened loneliness due to COVID-19 that was associated with worsened depression (62% vs 9%; p < .001) and anxiety (57% vs 9%; p < .001). Although loneliness ratings declined on average over time for some, loneliness persisted or worsened for a substantive subgroup of participants. Open-ended responses revealed challenges faced by this subgroup to include signs of poor emotional coping and discomfort with new technologies.

In addition to depression, Herron et al. 17 found that older adults' experiences of isolation and loneliness in the initial stages of the pandemic between the months of May and July 2020 were accompanied by feelings of a loss of autonomy, activities and social spaces (e.g., having coffee or eating out, volunteering, and going to church), as well as a lack of meaningful connections at home as factors influencing their sense of isolation and loneliness. Based on prior research, this reduced ability to be able to foster a meaningful existence, in the absence of social support, and contacts, may be expected to further foster painful and depressive experiences that reduce the will towards activity, as well as impacting immune health adversely. By contrast, where moderate support exists, along with opportunities for greater physical activity and more social contacts and participation, better physical and mental health attributes are likely to follow.

As such, Joffe 1 notes that the response to COVID-19 lockdowns may indeed be far more harmful to the wellbeing of older adults, and others than COVID-19 itself, regardless of health status. Activities that may be severely impacted and that can be considered to be life affirming when enabled are voluntary activities/work in the community, freedom to independently shop and take transport, freedom to interact with family members and others, plus freedom to obtain personal health services and counseling as required 18. To the contrary, social self-isolation, and distancing coupled with lockdowns of community resources and opportunities, which are unlikely to markedly impact current 2021 COVID-19 infection rates to a high degree 18, will potentially impact older adults’ ability to age well, as well as to offset COVID-19 risk, even if many older adults currently under lockdown remain uninfected.

Compelling data concerning social isolation that do exist, clearly indicate that a lack of adequate social contact and support produces the down regulation of the immune system, along with stress response genes and behavioral changes as identified in the context of basic studies of insects. While not directly related to humans, these data are undoubtedly highly relevant to consider in efforts to minimize any potentially analogous effect of the COVID-19 pandemic lockdowns on the older socially isolated adult. These negative responses, said to be attributable to deleterious alterations in neural circuitry, may inadvertently not affect their motivation and/or ability to pursue necessary preventive behaviors against COVID-19, but may lower the already compromised immune responses of many aging adults and with this, excess premature mortality rates, and hospitalizations 5. As examined by Scharf et al. 19 humans and other social mammals that experience isolation from their group tend to report this as stressful, as well as exhibiting behavioral and physiological anomalies that reduce fitness. An impaired ability to interact socially, can also impact changes in stress tolerance, gut-immune-brain axis mechanisms, a suite of physical and psychological health issues, and immune competence as verified by Donovan et al. 20 in an animal model where social isolation increased anxiety-like behaviors and impaired social affiliation. Isolation also resulted in sex- and brain region-specific alterations in neuronal activation, neurochemical expression, and microgliosis, as well as possible immune system weakness and frailty 21. According to Lozupone et al. 21 even the perception of social isolation such as loneliness, affects mental and physical health, as well as the integrity of the immune system, and has multiple associated cognitive and health-related sequelae. Hence, the currently reduced sources of support, along with heavy demands on personal resources, plus loneliness may be a factor associated with psychological distress and an undesirable set of outcomes in their own right in addition to increased COVID-19 susceptibility.

As per Du Preez et al.. 22 chronic stress can not only alter the immune system, as well as adult hippocampal neurogenesis and induce anxiety, but also depressive-like behavior. It can also impact immunity indirectly through its effect on sleep 23. This is because, social isolation, including the need to self-quarantine, the restricted mobility and social contact rules, and possible concerns about resource availability, fear of infection, questions about the duration of self-quarantine, can not only cause anxiety and depression, as well as stress, but insomnia or sleep quality and quantity changes, that may present a greater risk to the health of the individual than the virus alone, as this may aggravate systemic and lung inflammation during viral infections or induce harmful pro-inflammatory states, increased vulnerability to viral infections, and oxidative/antioxidant imbalances.

As outlined by Mattos Dos Santos et al. 24 social disruption stress may not only impact the functioning of the immune system, but it may cause several stress hormones evolved to defend against physical injury during periods of heightened risk to be released. While protective to some degree, if prolonged, these responses could leave the organism vulnerable to viral infections, as well as increases in pro-inflammatory gene states, while suppressing anti-viral gene expression. This series of alterations in transcriptional status is reportedly related to conditions of social stress, either through the presence of any hostile human contact, or increased predatory vulnerability due in part, to separation from the social group.

Raony et al. 25 indicate that for the above reasons and others, the impacts of the coronavirus 19 disease may go well beyond that of the respiratory system, also greatly affecting mental health, as well as coping responses, and perceptions of successful aging that impact these emotional responses 5. In addition to inaccurate or exaggerated perceptions and beliefs, and their emotional responses, that may mediate a possible association between COVID-19 and psychiatric outcomes, are fears evoked by the media, as well as those inherent in the context of the pandemic, the possible adverse effects of non personalized treatments or their absence, as well as financial stresses, excess physical stress, loneliness, sleeplessness, and further social isolation. This group also explored whether the relationship between COVID-19 and the host may also trigger more permanent changes in brain and behavior, such as neuroendocrine-immune changes, given evidence that social isolation and loneliness, can be shown to heighten unwanted chronic inflammatory responses 26.

As per Yeung et al. 5 the overlapping issues of social distancing, including the temporary closure of public entertainment places, such as theatres and fitness centers, as well as health resources, and others, along with the high perceived uncertainty and susceptibility among local resident because of the lack of information, conflicting information, and inability to possibly cope independently at best has been found to precipitate panic and anger, while considerably interrupted work arrangements if applicable, as well as key life affirming social relationships.

Although positive perceptions of ‘successful aging’ are found to impact the wellbeing of older adults more favorably than not 5, favorable perceptions of wellbeing that predict ‘successful or healthy aging’ may be highly challenging to achieve. Indeed, the effects of lockdowns on mental health, along with a possible loss of personal efficacy or control, as well as valued and essential activities including opportunities for older isolated adults to interact and partner with empathetic formal and informal providers and caregivers directly is likely to induce a highly undesirable array of negative emotional, social, and physical impacts that might be irreversible. Moreover, in failing to partner with older adults and to understand their particular social needs and others, policy makers, may find more distress being engendered than desirable among this group 33, especially where fear based technical messages persistently abound, rather than culturally tailored informative resources, and clear options, in different formats and languages. Moreover, rather than hoping technology or robots 11 will be sufficiently helpful in overcoming the repercussions of lockdowns in the older community dwelling adults, regardless of level of ability or disability, a dedicated focus on the provision of carefully construed comprehensive holistic care strategies appears strongly indicated. This includes, but is not limited to the safe provision of required life-affirming forms of social support 27, opportunities to enjoy sound nutrition practices, an active lifestyle, peer support specialists and support groups, and counseling 28. As well optimizing desirable environmental factors, including those that promote moderate physical activity, could make an immense difference in all likelihood to the success of any government policy in the fight against COVID-19, as well as securing the long-term well-being and ‘successful aging’ of its older community living population 29. 

Alternately, as per Figure 1, despite their ‘laudable intentions’, it is highly possible that lockdown and distancing regulations designed to mitigate the spread and acquisition of COVID-19 among older community dwelling elderly adults and others, may indeed result in unanticipated as well as overwhelming multiple undesirable health outcomes 14, if the role of other health determinants and the importance of social factors in this regard is largely ignored. Moreover, the prolonged absence or inaccessibility for many community dwelling older adults to consistent, timely, empathetic and compassionate care, and needed medical and surgical attention, and a temporary replacement of desired personal counselling services with online social media and technological strategies may fail to provide an optimal substitute or viable solution to health issues other than COVID-19 that require attention. This situation is likely to be especially dire in the event the individual cannot effectively and proactively contribute to their own well-being independently in real time and on a consistent basis, or they have limited literacy, needed resources, and technical skills. Moreover, even if this set of determinants is not an issue, the ability to manage one’s health condition optimally in the face of travel restrictions, cuts in services, unknown time lines, and others can be expected to have an additionally negative individual and collective impact. In particular, poor health stemming from artificially imposed social restrictions may not only heighten COVID-19 risk 14, but it may engender cardiovascular disease, the number one killer, while hastening mental health declines 30. Isolation and lockdowns may also be expected to exacerbate current health problems 30 such as, obesity, depression, and frailty.

On the other hand, carefully construed parallel initiatives to assist vulnerable older adults under lockdown to receive needed support as soon as possible may combat this host of adverse social isolation associated impacts to a high degree. In particular, efforts to assist older adults with any required home modifications, certain forms of equipment, plus personalized home health care visits and phone calls, safe access to gyms, community based centre and religious resources, peers, local shops, and others as indicated, may be especially helpful in averting declining health outcomes ^{31 and COVID}.

By 2030, the numbers of older adults worldwide is anticipated to rise substantively. However, while many older adults today will live to become centurions, many who are alive today, may not reach their optimal potential at all successfully, if the pandemic associated precautionary social distancing rules, restrictions, ordinances, and others are not compensated for or minimized in the population of older adults in a meaningful way as soon as possible.

To the contrary, the prevailing widespread socially restrictive initiatives designed to preserve life and wellbeing, may not only reduce those key attributes of resilience and the ability to achieve personally valued goals 40, upon which the idea of successful aging is conceptualized, but the multiple ongoing restrictions may produce feelings of fear, depression and distress that impede desirable self management practices, including the key importance of physical activity practices 36.

Moreover, since successful aging is partially premised on five key categories of perception: including social wellbeing, psychological wellbeing, physical health, spirituality and transcendence, plus environmental and economic security 37, any disconnect between these desirable attributes amidst any long-term socially limiting COVID-19 isolating imperatives may well foster a host of negative repercussions Figure 1. As such, disruptions in the attributes of social cohesion and resource availability, plus perceptions of a strong sense of community, which are vital health promoting elements 46, which may decline, may be expected to adversely impact those aspects of well-being that are deemed key to aging well , and being able to minimize adverse feelings of despair, fear, stress, depression, anxiety, loneliness and lack of meaning that can heighten COVID-19 risk as well as exacerbate or foster one or more chronic health conditions, especially those linked to COVID-19, such as obesity, and cardiovascular disease 44. Alternately, placing more emphasis on what is most important as well as required by the individual older adult - in light if their unique personal needs and situation, and perhaps helping them to feel their artificially imposed socially restrictive situation is actually helpful and a contribution to many others 43, even if it is emotional draining, can surely in turn, promote their sense of personal efficacy and worth, despite being lonely and isolated. It is also probable that drawing on the strengths of the older adult and helping them to proactively attempt to maintain a full and independent life by means of their own efforts over the currently stressful pandemic period, coupled with efforts to combat loneliness 38, may further prevent excess debility, while promoting regenerative or reparative states, where the individual may feel very satisfied and thus successful-all things considered. To the contrary, if nothing is done to translate and apply evidence supporting primary prevention strategies, implemented immediately, to foster an optimally safe, as well as supportive and enriching living environments, offsetting the prevalence as well as the severity of COVID-19 and comorbid health complications through isolation alone seems unlikely 1415.

 These strategies may include, but are not limited to home adaptations to limit falls injuries often due to secondary depression 34, the provision of an adequate nutritious food supply 36, medication oversight, opportunities for modest exercise 36, and companionship 38. Moreover, these efforts should be sustained, rather than short-lived to avert long-term potentially preventable decrements in health 36. To this end, more marketing and advocacy by aging foundations as to why it is imperative to protect older adults who are presently confined inadvertently in efforts to protect them against COVID-19 is strongly recommended. As well, to avert unwanted declines in health status among older homebound adults, especially physical and psychosocial declines 12 among women who live alone 46, more expert guidance and other efforts by physicians and clinicians to help combat or prevent excess depression and anxiety and improve coping skills in this group using diverse communication strategies, will undoubtedly be very helpful in advancing those perceptions of personal efficacy that foster motivation for self-protection and well-being, despite being exposed to multiple COVID-19 related risks 233354648. By contrast, although not well studied or incorporated into current modeling analogies, a pervasive focus on the immense importance of extended lockdowns, social distancing, isolation, and pauses in community services and activities, may be expected to be place high numbers of older adults at risk for both current as well as poor future health and excess mortality rates and morbidity rates, as well as limiting their ability to overcome remediable current health challenges. Indeed, even if life returns to normal and older adults in the community remain unaffected directly by COVID-19 infections, it appears that as the lockdown, social distancing, and stay at home orders persist, society will experience extremely high potentially preventable social and economic costs 40. Older adults with disabilities as well as multi morbidities are especially likely to incur high rates of excess suffering owing to any prolonged and unexpectedly imposed isolating socially and emotionally impactful stress related social disruptions,and ordinances 3641, and dissatisfaction with communication situations 47, unless preferentially and thoughtfully targeted in a timely compassionate way 48.

In this regard, and to mitigate potentially catastrophic health and social outcomes for societies post COVID-19 of excessively stressful negatively impactful lockdowns 47, several promising ideas have been put forth that appear worthy of consideration. Among those are active rather than passive strategies designed to build resilience 384045, as well as appropriate strategies to minimize any excess psychological suffering, stress and anxiety, unmet medical needs of those experiencing persistent loneliness 6, and required financial assistance 49. Since desirable social communication opportunities are found to buffer loneliness 47, barriers to technology-based social interaction 16 as well as physical activity barriers 6, along with other barriers to maintaining optimal mental, nutritional, and social well-being also need to be addressed 153949, regardless of health status 40.

As well, carefully examining whether the negative consequences of large-scale lockdowns are effective or not should receive due consideration 50